Amy R. Howell
Professor/Chemistry

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Scholarly Contributions

84 Scholarly Contributions

70
Journal Articles
13
Poster/Presentations
1
Patent and Intellectual Property
Natural Product-inspired Glycolipids Providing Enhanced or Selective Activation of iNKT Cells
2012
Amy R Howell
Research Type: Poster/Presentation

A molecular basis for the exquisite CD1d-restricted antigen specificity and functional responses of natural killer T cells.
2011
M S Thakur, D G Pellicci, S Keshipeddy, A G Brooks, A P Uldrich, O Patel, S A Porcelli, K S Wun, Amy R Howell, D I Godfrey, G S Besra, G Cameron, Stewart Richardson, P A Illarionov, J McCluskey, J Rossjohn, S S Pang, M H Young, L Gapin, L C Sullivan
Research Type: Journal Article

A rapid fluorescence-based assay for classification of iNKT cell activating glycolipids.
2011
S K Chung, P Arora, J H Lee, G Bricard, M M Venkataswamy, A Baena, Q Li, S A Porcelli, K C Seo, N Veerapen, P A Illarionov, R Ndonye, J J Park, Amy R Howell, G S Besra, Y T Chang
Research Type: Journal Article

Mouse and human iNKT cell agonist β-mannosylceramide reveals a distinct mechanism of tumor immunity.
2011
D S Khursigara, J A Berzofsky, S A Porcelli, E Ambrosino, B F Castillo, 2nd, H Y Kim, L Izhak, M Khalili, R Raju, P Illarionov, M Terabe, Amy R Howell, G S Besra, J J O'Konek
Research Type: Journal Article

Vβ2 Natural Killer T Cell Antigen Receptor-mediated Recognition of CD1d-Glycolipid Antigen
2011
Thierry Mallevaey, Jamie Rossjohn, Gurdyal S. Besra, Amy R Howell, Jingjing Zhang, Mugdha Bhati, Steven A Porcelli, Romain Bedel, Melissa McKnight, Onisha Patel, Laurent Gapin, Stewart K Richardson, Daniel G Pellicci, Andrew G Brooks, Lucy C Sullivan, James McCluskey, Lars Kjer-Nielsen, Dale I Godfrey, Adam P Uldrich
Research Type: Journal Article

Glycolipids that elicit IFN-γ-biased responses from natural killer T cells.
2011
A Birkholz, Y Li, M Kronenberg, A J Tyznik, S A Porcelli, Amy R Howell, R So, A Khurana, S Chitale, P Arora, J Wang, D M Zajonc, E Farber, E Girardi
Research Type: Journal Article

Novel Glycolipids that Elicit IFN-γ responses from Natural Killer T Cells
2011
J Wang, Amy R Howell, Aaron J Tyznik, Archana Khurana, Dirk M Zajonc, Alysia Birkholz, Yalli Li, Steven A Porcelli, Sampada C Chitale, Elisa Farber, Regina C So, Pooja Arora, Enrico Girardi, Mitchell Kronenberg
Research Type: Journal Article

Access to Oxetane-containing psico-Nucleosides from 2-Methyleneoxetanes: A Role for Neighboring Group Participation?
2011
Paul R Rablen, Bryan T Whiting, John M Rowley, Yanke Liang, Martha M Morton, Nathan Hnatiuk, Geoffrey W Coates, Amy R Howell
Research Type: Journal Article

4-Oxaspiro[2.3]hexanes: A Novel Platinum(II) Catalyzed Transformation
2011
Meena Thakur, Rosa Taboada, Amy R Howell, Sampada Chitale
Research Type: Poster/Presentation

Part I. Natural Killer T Cell Activation by Glycolipids; Part II: Transformations of Strained Heterocycles
2011
Amy R Howell
Research Type: Poster/Presentation

Efforts Towards a Formal Synthesis of Laureatin: An Unexpected NBS-mediated Skeletal Rearrangement
2011
Santosh Keshipeddy, Isamir Martinez, Bernard F Castillo, Martha D Morton, Amy R Howell
Research Type: Poster/Presentation

A CD1d-dependent antagonist inhibits the activation of invariant NKT cells and prevents development of allergen-induced airway hyperreactivity.
2010
X Li, S B Wilson, P Stock, Amy R Howell, K O Yu, T Shiratsuchi, J Kerzerho, W Yang, O Akbari, M Kronenberg, V Lombardi, B A Sullivan, S A Porcelli, M Tsuji, A K Singh, N E Hnatiuk
Research Type: Journal Article

Unexpected cleavage of 2-azido-2-(hydroxymethyl)oxetanes: conformation determines reaction pathway?
2010
E Farber, J Herget, Amy R Howell, J A Gascón
Research Type: Journal Article

Α-galactosylceramide analogs with weak agonist activity for human iNKT cells define new candidate anti-inflammatory agents.
2010
N Veerapen, S A Porcelli, J S Im, Y T Chang, K O Yu, G S Besra, M M Venkataswamy, G Bricard, P A Illarionov, Q Li, Amy R Howell, R M Ndonye
Research Type: Journal Article

Kinetics and cellular site of glycolipid loading control the outcome of natural killer T cell activation.
2009
K O Yu, M M Venkataswamy, A Molano, G Bricard, J S Im, E S Jerud, G S Besra, P Cresswell, W Yuan, A Baena, Amy R Howell, M F Goldberg, S A Porcelli, P A Illarionov, R M Ndonye, I Baine, P Arora, Y T Chang
Research Type: Journal Article

Adaptability of the semi-invariant natural killer T-cell receptor towards structurally diverse CD1d-restricted ligands.
2009
Amy R Howell, P G Wang, D G Pellicci, C Xia, Y Zhang, J McCluskey, Y Kinjo, O Patel, W Chen, L Kjer-Nielsen, D M Zajonc, D I Godfrey, Stewart Richardson, W C Florence, L E Gordy, J Scott-Browne, K O Yu, L Gapin, J Rossjohn, S Joyce, K Hayakawa, S A Porcelli, S Keshipeddy
Research Type: Journal Article

Recognition of lyso-phospholipids by human natural killer T lymphocytes.
2009
X Wang, D G Cox, J E Gumperz, Amy R Howell, N Veerapen, W H Hildebrand, E J Adams, G S Besra, R M Ndonye, L Scharf, J L Lockridge, L M Fox, X Chen, M E Cook, D L Trott
Research Type: Journal Article

Synthesis and evaluation of an acyl-chain unsaturated analog of the Th2 biasing, immunostimulatory glycolipid, OCH.
2009
G Bricard, R Raju, Amy R Howell, G Velmourougane, G S Besra, J S Im, S A Porcelli
Research Type: Journal Article

Synthesis and evaluation of 3''- and 4''-deoxy and -fluoro analogs of the immunostimulatory glycolipid, KRN7000.
2009
M Kronenberg, B F Castillo, Stewart Richardson, R Raju, R Severins, Amy R Howell, M Thakur
Research Type: Journal Article

T cell receptor CDR2 beta and CDR3 beta loops collaborate functionally to shape the iNKT cell repertoire.
2009
V Cerundolo, O Patel, J L Matsuda, Amy R Howell, D G Pellicci, J P Scott-Browne, L Kjer-Nielsen, M H Young, T Mallevaey, J McCluskey, M Thakur, Stewart Richardson, L Gapin, J Rossjohn, D I Godfrey, P Marrack
Research Type: Journal Article