Amy R. Howell
Professor/Chemistry

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Kinetics and cellular site of glycolipid loading control the outcome of natural killer T cell activation.
2009
K O Yu, M M Venkataswamy, A Molano, G Bricard, J S Im, E S Jerud, G S Besra, P Cresswell, W Yuan, A Baena, Amy R Howell, M F Goldberg, S A Porcelli, P A Illarionov, R M Ndonye, I Baine, P Arora, Y T Chang
Research Type: Journal Article

Adaptability of the semi-invariant natural killer T-cell receptor towards structurally diverse CD1d-restricted ligands.
2009
Amy R Howell, P G Wang, D G Pellicci, C Xia, Y Zhang, J McCluskey, Y Kinjo, O Patel, W Chen, L Kjer-Nielsen, D M Zajonc, D I Godfrey, Stewart Richardson, W C Florence, L E Gordy, J Scott-Browne, K O Yu, L Gapin, J Rossjohn, S Joyce, K Hayakawa, S A Porcelli, S Keshipeddy
Research Type: Journal Article

Recognition of lyso-phospholipids by human natural killer T lymphocytes.
2009
X Wang, D G Cox, J E Gumperz, Amy R Howell, N Veerapen, W H Hildebrand, E J Adams, G S Besra, R M Ndonye, L Scharf, J L Lockridge, L M Fox, X Chen, M E Cook, D L Trott
Research Type: Journal Article

Synthesis and evaluation of an acyl-chain unsaturated analog of the Th2 biasing, immunostimulatory glycolipid, OCH.
2009
G Bricard, R Raju, Amy R Howell, G Velmourougane, G S Besra, J S Im, S A Porcelli
Research Type: Journal Article

Synthesis and evaluation of 3''- and 4''-deoxy and -fluoro analogs of the immunostimulatory glycolipid, KRN7000.
2009
M Kronenberg, B F Castillo, Stewart Richardson, R Raju, R Severins, Amy R Howell, M Thakur
Research Type: Journal Article

T cell receptor CDR2 beta and CDR3 beta loops collaborate functionally to shape the iNKT cell repertoire.
2009
V Cerundolo, O Patel, J L Matsuda, Amy R Howell, D G Pellicci, J P Scott-Browne, L Kjer-Nielsen, M H Young, T Mallevaey, J McCluskey, M Thakur, Stewart Richardson, L Gapin, J Rossjohn, D I Godfrey, P Marrack
Research Type: Journal Article

Alpha-S-GalCer: synthesis and evaluation for iNKT cell stimulation.
2008
J Paulsen, M L Blauvelt, S Brian Wilson, Amy Anderson, Amy R Howell, W Jaung, M Khalili
Research Type: Journal Article

Natural killer T-cell autoreactivity leads to a specialized activation state.
2008
J E Gumperz, X Chen, G F Painter, A Huttenlocher, X Wang, L Rodenkirch, R M Ndonye, G S Besra, N Veerapen, Amy R Howell, D Gibson, S Wernimont, W Simonson
Research Type: Journal Article

SGalCer Synthesis and evaluation for iNKT cell stimulation
2008
Amy Anderson, Amy R Howell
Research Type: Journal Article

Synthesis of epi-oxetin via a serine-derived 2-methyleneoxetane.
2008
Amy R Howell, M L Blauvelt
Research Type: Journal Article

A minimal binding footprint on CD1d-glycolipid is a basis for selection of the unique human NKT TCR.
2008
Stewart Richardson, R Koh, T Beddoe, D I Godfrey, Amy R Howell, M Thakur, L Kjer-Nielsen, L Gapin, J P Scott-Browne, J Rossjohn, K S Wun, N A Borg, J McCluskey
Research Type: Journal Article

Natural Sphingomonas glycolipids vary greatly in their ability to activate natural killer T cells.
2008
K Kawahara, P H Seeberger, B Pei, Stewart Richardson, D Wu, M Imamura, C H Wong, Amy R Howell, A Khurana, M Fujio, S Bufali, M Kronenberg, Y Kinjo, R Raju
Research Type: Journal Article

Cross metathesis of alpha-methylene lactones II: gamma- and delta-lactones.
2007
T Le, C D Taylor, L J Allen, R Raju, Amy R Howell
Research Type: Journal Article

Production and characterization of monoclonal antibodies against complexes of the NKT cell ligand alpha-galactosylceramide bound to mouse CD1d.
2007
G S Besra, Amy R Howell, J S Im, P A Illarionov, K O Yu, R M Ndonye, S A Porcelli
Research Type: Journal Article

Rapid identification of immunostimulatory alpha-galactosylceramides using synthetic combinatorial libraries.
2007
P A Illarionov, Q Li, Amy R Howell, K O Yu, K Diaz, R M Ndonye, S A Porcelli, G S Besra, E S Jerud, Y T Chang, G Bricard
Research Type: Journal Article

Improved outcomes in NOD mice treated with a novel Th2 cytokine-biasing NKT cell activator.
2007
T P Dilorenzo, S A Porcelli, G S Besra, Amy R Howell, A Molano, T Takaki, P Santamaria, J S Im, P Illarionov, R Ndonye, I Baine, C Forestier, E S Jerud
Research Type: Journal Article

Cross metathesis with strained exocyclic enones: synthesis of 3-alkylideneoxetan-2-ones from 3-methyleneoxetan-2-ones.
2006
Amy R Howell, R Raju
Research Type: Journal Article

T-bet concomitantly controls migration, survival, and effector functions during the development of Valpha14i NKT cells.
2006
Q Zhang, L Gapin, J L Matsuda, Stewart Richardson, Amy R Howell, R Ndonye
Research Type: Journal Article

Multiphoton excited fabrication of collagen matrixes cross-linked by a modified benzophenone dimer: bioactivity and enzymatic degradation.
2005
G D Pins, L P Cunningham, K A Bush, P J Campagnola, Amy R Howell, R Taboada, J Wang, S Basu
Research Type: Journal Article

Synthesis and evaluation of sphinganine analogues of KRN7000 and OCH.
2005
D P Izmirian, S A Porcelli, K O Yu, M F Dunn, Stewart Richardson, Amy R Howell, A Khurana, M Kronenberg, R M Ndonye
Research Type: Journal Article