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Preventing and treating T cell immunodeficiency in older adults by ESC- and iPSC-derived thymic epithelial cells

Sponsor: DHHS/NIH/National Institutes of Health

Authors: Laijun Lai

2025-12-01 - 2030-11-30

Modeling and treating type 1 diabetes by ESC- and iPSC-derived cells

Sponsor: DHHS/NIH/National Institutes of Health

Authors: Laijun Lai

2025-12-01 - 2030-11-30

Protective role of TAPBPL in autoimmune encephalomyelitis

Sponsor: DHHS/NIH/National Institutes of Health

Authors: Laijun Lai

2025-10-01 - 2030-09-30

Regulating immune cells to ameliorate Alzheimer's disease

Sponsor: DHHS/NIH/National Institutes of Health

Authors: Laijun Lai

2025-10-01 - 2030-09-30

Protective role of TAPBPL in autoimmune encephalomyelitis

Sponsor: DHHS/NIH/National Institutes of Health

Authors: Laijun Lai

2024-04-01 - 2029-03-31

Mechanisms of TAPBPL effect in acute graft-versus-host disease

Sponsor: DHHS/NIH/National Human Genome Research Institute

Authors: Laijun Lai

2023-10-01 - 2028-09-30

Regulating Immune Cells to Ameliorate Alzheimer's Disease

Sponsor: DHHS/NIH/National Institute on Aging

Authors: Laijun Lai

2023-10-01 - 2028-09-30

The effects of ERMAP on rheumatoid arthritis

Sponsor: DHHS/NIH/National Human Genome Research Institute

Authors: Laijun Lai

2023-10-01 - 2025-09-30

Treating T cell immunodeficiency among older adults by a recombinant Foxn1 fusion protein

Sponsor: DHHS/NIH/National Institute on Aging

Authors: Laijun Lai

Funding: $1,449,000

2023-06-01 - 2026-05-31

Mechanisms of Skint8 effect in T cell functions

Sponsor: DHHS/NIH/National Institutes of Health

Authors: Laijun Lai

2023-04-01 - 2025-03-31

Using patients' own iPSC-derived thymic epithelial cells to model and treat autoimmune diseases.

Sponsor: DHHS/NIH/National Institutes of Health

Authors: Laijun Lai

2023-04-01 - 2028-03-31

Mechanisms of CD300c effect in acute graft-versus-host disease

Sponsor: DHHS/NIH/National Institutes of Health

Authors: Laijun Lai

2023-04-01 - 2028-03-31

Protective role of TAPBPL in autoimmune encephalomyelitis

Sponsor: DHHS/NIH/National Institute of Allergy and Infectious Diseases

Authors: Laijun Lai

2023-04-01 - 2028-03-31

Modeling and treating T cell immunodeficiency in CHARGE syndrome by ESC- and iPSC-derived thymic epithelial cells

Sponsor: DHHS/NIH/National Institute of Allergy and Infectious Diseases

Authors: Laijun Lai

Funding: $2,356,927

2023-02-01 - 2028-01-31

Treating type 1 diabetes by a novel immune checkpoint molecule CD300c

Sponsor: Harrington Discovery Institute

Authors: Laijun Lai

2022-12-01 - 2024-11-30

Regulating immune cells to ameliorate Alzheimer's disease

Sponsor: DHHS/NIH/National Institute on Aging

Authors: Laijun Lai

2022-09-01 - 2027-08-31

Modeling and preventing chronic graft-vs-host disease by ESC- and iPSC-derived thymic epithelial cells

Sponsor: DHHS/NIH/National Heart, Lung, and Blood Institute

Authors: Laijun Lai

2022-09-01 - 2027-08-31

Preventing and treating T cell immunodeficiency in the older adult by ESC- and iPSC-derived thymic epithelial cells

Sponsor: DHHS/NIH/National Institute of Allergy and Infectious Diseases

Authors: Laijun Lai

2022-09-01 - 2027-08-31

Targeting the CD300c inhibitory pathway to prevent and treat melanoma

Sponsor: DOD/Defense Health Agency

Authors: Laijun Lai

2022-07-01 - 2025-06-30

ERMAP Affects Alzheimer's Disease Development By Regulating Immune Cells

Sponsor: DHHS/NIH/National Institute on Aging

Authors: Laijun Lai

2022-07-01 - 2027-06-30

The effects of CS300c on acute graft-versus-hose disease

Sponsor: DHHS/NIH/National Heart, Lung, and Blood Institute

Authors: Laijun Lai

2022-07-01 - 2027-06-30

Treating T cells immunodeficiency in CHARGE syndrome by ESC- and iPSC-derived cells

Sponsor: DHHS/NIH/National Institute of Allergy and Infectious Diseases

Authors: Laijun Lai

2022-07-01 - 2027-06-30

Preventing and treating T cell immunodeficiency in the older adult by iPSC-derived thymic epithelial cells

Sponsor: DHHS/NIH/National Institute on Aging

Authors: Laijun Lai

2022-04-01 - 2027-03-31

The role of immune cells in Alzheimer's disease development

Sponsor: DHHS/NIH/National Institute on Aging

Authors: Laijun Lai

2022-04-01 - 2027-03-31

Using ESC- and iPSC-derived thymic epithelial cells expressing autoantigens to treat T1D

Sponsor: DHHS/NIH/National Institute of Diabetes and Digestive and Kidney Diseases

Authors: Laijun Lai

2022-04-01 - 2027-03-31

Mechanisms of CD300c effect in autoimmune encephalomyelitis

Sponsor: DHHS/NIH/National Institute of Allergy and Infectious Diseases

Authors: Laijun Lai

2022-04-01 - 2027-03-31

Targeting CD300c on antitumor immune therapy

Sponsor: DHHS/NIH/National Institute of Allergy and Infectious Diseases

Authors: Laijun Lai

2021-12-01 - 2023-11-30

Cellular and molecular regulations of thymic epithelial cell development from embryonic stem cells

Sponsor: DHHS/NIH/National Institute of Allergy and Infectious Diseases

Authors: Laijun Lai

2021-12-01 - 2026-11-30

The effects of CD300c on acute graft-versus-host disease

Sponsor: DHHS/NIH/National Heart, Lung, and Blood Institute

Authors: Laijun Lai

2021-12-01 - 2026-11-30

Treating T cell immunodeficiency in CHARGE syndrome by ESC- and iPSC-derived cells

Sponsor: DHHS/NIH/National Institute of Allergy and Infectious Diseases

Authors: Laijun Lai

2021-12-01 - 2026-11-30

The effects of ERMAP protein and its antibody in Alzheimer's disease development

Sponsor: BrightFocus Foundation

Authors: Laijun Lai

2021-07-01 - 2024-06-30

The effects of Skint8 protein on type 1 diabetes

Sponsor: DHHS/NIH/National Institute on Aging

Authors: Laijun Lai

2021-07-01 - 2023-06-30

Preventing and treating T cell immunodeficiency in the older adult by iPSC-derived thymic epithelial cells

Sponsor: DHHS/NIH/National Institute on Aging

Authors: Laijun Lai

2021-07-01 - 2026-06-30

The role of immune cells in Alzheimer's disease development

Sponsor: DHHS/NIH/National Institute on Aging

Authors: Laijun Lai

2021-07-01 - 2026-06-30

The effects of Skint8 protein on acute graft-versus-host disease in mice

Sponsor: DHHS/NIH/National Institute of Allergy and Infectious Diseases

Authors: Laijun Lai

2021-07-01 - 2023-06-30

Treating T cell immunodeficiency among older adults by a recombinant Foxn1 fusion protein

Sponsor: DHHS/NIH/National Institute on Aging

Authors: Laijun Lai

Funding: $1,891,750

2021-06-15 - 2023-05-31

Modeling Chronic Graft-versus-host Disease by ESC-derived Cells

Sponsor: DHHS/NIH/National Institutes of Health

Authors: Laijun Lai

2021-04-01 - 2023-03-31

Immune response to a SARS-CoV-2 spike protein trimer paired with a novel adjuvant in humanized mice

Sponsor: DHHS/NIH/National Institutes of Health

Authors: Laijun Lai

2021-04-01 - 2023-03-31

Modeling and Treating T cell immunodeficiency in CHARGE syndrome by ESC- and iPSC-derived cells

Sponsor: DHHS/NIH/National Institutes of Health

Authors: Laijun Lai

2021-04-01 - 2026-03-31

The effects of BTNL2 on experimental autoimmune enciphalimyelitis

Sponsor: DHHS/NIH/National Institute of Allergy and Infectious Diseases

Authors: Laijun Lai

Funding: $442,750

2021-03-04 - 2025-02-28

The effects of CD300c on acute graft-versus-host disease

Sponsor: DHHS/NIH/National Institutes of Health

Authors: Laijun Lai

2020-12-01 - 2025-11-30

Preventing and treating T cell imminodeficienc in the elderly by ESC- and iPSC- derived thymic epithelial cells

Sponsor: DHHS/NIH/National Institutes of Health

Authors: Laijun Lai

2020-12-01 - 2025-11-30

Epitope-based recombinant protein vaccine for COVID-19

Sponsor: DHHS/NIH/National Institutes of Health

Authors: Laijun Lai

2020-12-01 - 2022-11-30

The role of CD300c in experimental autoimmune encephalomyelitis

Sponsor: DHHS/NIH/National Institutes of Health

Authors: Laijun Lai

2020-12-01 - 2022-11-30

The Effects of Skint8 protein on type 1 diabetes

Sponsor: DHHS/NIH/National Institutes of Health

Authors: Laijun Lai

2020-12-01 - 2022-11-30

Modeling chronic graft-versus-host disease by ESC-derived cells

Sponsor: DHHS/NIH/National Institutes of Health

Authors: Laijun Lai

2020-12-01 - 2022-11-30

Modeling and Treating E cell immunodeficiency in CHARGE Syndrome by ESC- and iPSC-dervied cells

Sponsor: DHHS/NIH/National Institutes of Health

Authors: Laijun Lai

2020-07-01 - 2025-06-30

CD300c ameliorates acute graft-versus-host disease

Sponsor: DHHS/NIH/National Institutes of Health

Authors: Laijun Lai

2020-04-01 - 2025-03-31

Modeling and Treating Type 1 diabetes by ESC- and iPSC-derived thymic epithelial cells

Sponsor: DHHS/NIH/National Institutes of Health

Authors: Laijun Lai

2020-04-01 - 2025-03-31

Preventing and treating T cell immunodeficiency in the elderly by recombinant Foxn1 fusion protein

Sponsor: DHHS/NIH/National Institutes of Health

Authors: Laijun Lai

2020-04-01 - 2025-03-31

Preventing and treating T cell immunodeficiency in the elderly by ESC- and iPsc-derived thymic epithelial cells

Sponsor: DHHS/NIH/National Institutes of Health

Authors: Laijun Lai

2020-04-01 - 2025-03-31

The effect of CD3000 protein on inhibiting autoimmunity in a multiple sclerosis animal model

Sponsor: Almirall

Authors: Laijun Lai

2019-12-01 - 2021-11-30

Preventing and Treating T Cell Immunodeficiency in the Elderly by ESC- and iPSC-Derived Thymic Epithelial Cells

Sponsor: DHHS/NIH/National Institutes of Health

Authors: Laijun Lai

2019-02-15 - 2024-02-14

Modeling and Preventing Chronic Graft-Versus Host Disease by ESC-Derived Thymic Epithelial Cells

Sponsor: DHHS/NIH/National Institutes of Health

Authors: Laijun Lai

2019-01-01 - 2023-12-31

rIL-7/HGFbeta Directs HSC Differentiation from HSC Precursors

Sponsor: DHHS/NIH/National Institutes of Health

Authors: Laijun Lai

2019-01-01 - 2023-12-31

Treating T Cell Immunodeficiency in DiGeorge Syndrome by ESC- and iPSC-Derived Thymic Epithelial Cells

Sponsor: Connecticut Innovations

Authors: Laijun Lai

Funding: $675,500

2017-06-15 - 2021-06-15

The Effects of rIL-7/HGFbeta on Graft-Versus-Host Disease

Sponsor: DHHS/NIH/National Institutes of Health

Authors: Laijun Lai

2017-04-01 - 2022-03-30

Modeling and Correcting Immunodeficiency in DiGeorge Syndrome by ESC- and iPSC-Derived Thymic Epithelial Cells

Sponsor: DHHS/NIH/National Institutes of Health

Authors: Laijun Lai

2016-12-01 - 2021-11-30

Modeling and Preventing Graft-Versus-Host Disease by ESC-Derived Thymic Epithelial Cells

Sponsor: DHHS/NIH/National Institutes of Health

Authors: Laijun Lai

2016-12-01 - 2021-11-30

Generation of Hematopoietic Stem Cells (HSCs) from Human ESC-Derived or Adult HSC Precursors

Sponsor: Connecticut Innovations

Authors: Laijun Lai

2016-11-01 - 2020-10-31

The Effects of rIL-7/HGFbeta on Graft-Versus-Host Disease

Sponsor: DHHS/NIH/National Institutes of Health

Authors: Laijun Lai

2016-07-01 - 2021-06-30

rIL-7/HGFbeta Directs HSC Differentiation from HSC Precursors

Sponsor: DHHS/NIH/National Institutes of Health

Authors: Laijun Lai

2016-07-01 - 2021-06-30

Transplantation of ESC-Derived Thymic Epithelial Progenitors Expressing Autoantigen(s) Ameliorating Experimental Autoimmune Encephalomyelitis

Sponsor: DHHS/NIH/National Institute of Allergy and Infectious Diseases

Authors: Laijun Lai

Funding: $1,948,900

2016-02-15 - 2022-01-31

Enhancing T Cell Regeneration After Hematopoietic Stem Cell Transplantation by Recombinant Human IL-7/HGF

Sponsor: Connecticut Innovations

Authors: Laijun Lai

2016-02-01 - 2019-01-31

rIL-7/HGFbeta Directs HSC DIfferentiation from HSC Precursors

Sponsor: DHHS/NIH/National Institutes of Health

Authors: Laijun Lai

2015-12-01 - 2020-11-30

Generation of Hematopoietic Stem Cells (HSCs) From Human ESC-Derived or Adult HSC Precursors Cells

Sponsor: CT Department of Public Health

Authors: Laijun Lai

2015-11-01 - 2019-10-31

Enhancing T Cell Regeneration After Hematopoietic Stem Cell Transplantation by Recombinant Human IL-7/HGF

Sponsor: Connecticut Innovations

Authors: Laijun Lai

2015-11-01 - 2018-10-31

Preventing or Reversing Age-Related T Cell Immunodeficiency by Human ESC- and iPSC-Derived Cells

Sponsor: CT Department of Public Health

Authors: Laijun Lai

2015-09-01 - 2019-08-31

Preventing or Reversing Age-Associated Thymic Involution by Human ESC- and iPSC-Derived Thymis Epithelial Cells

Sponsor: DHHS/NIH/National Institutes of Health

Authors: Laijun Lai

2015-07-01 - 2020-06-30

rIL-7/HF Gbeta Directs HSC Differentiation from HSC Precursors

Sponsor: DHHS/NIH/National Institutes of Health

Authors: Laijun Lai

2015-07-01 - 2020-06-30

Antitumor Effects of Novel Hybrid Cytokines in Lung Cancer

Sponsor: CT Department of Public Health

Authors: Laijun Lai

2015-05-01 - 2017-04-30

Inihibition of Breast Cancer Growth and Metastasis by Hybrid Cytokines

Sponsor: DOD/Department of Defense

Authors: Laijun Lai

2015-05-01 - 2018-04-30

Preventing or Reversing Age-Associated Thymic Atrophy by Human ESC- and iPSC-Derived Cells

Sponsor: CT Department of Public Health

Authors: Laijun Lai

2014-10-01 - 2018-09-30

Antitumor Effects of Novel Hybrid Cytokines in Lung Cancer

Sponsor: CT Department of Public Health

Authors: Laijun Lai

2014-05-01 - 2015-04-30

Thymic Epithelial Cell Development from Embryonic Stem Cells

Sponsor: DHHS/NIH/National Institute of Allergy and Infectious Diseases

Authors: Laijun Lai

2014-01-01 - 2018-12-31

Thymic Epithelial Cell Development from Embryonic Stem Cells

Sponsor: DHHS/NIH/National Institute of Allergy and Infectious Diseases

Authors: Laijun Lai

2013-04-01 - 2018-03-31

Inducing Immune Tolerance to hESCs and their Derivatives by the hESC-Derived Thymic Epithelial Cells

Sponsor: CT Department of Public Health/Connecticut Innovations

Authors: Laijun Lai

Funding: $750,000

2012-11-01 - 2016-11-01

Immunotherapy of Melanoma and Colon Cancer by a Recombinant IL-7/HGFB Protein

Sponsor: CT Department of Public Health/University of Connecticut Health Center

Authors: Laijun Lai

Funding: $356,445

2012-03-01 - 2013-08-31

Generation of Hematopoietic Stem Cell and T-cell Progenitors from Human ESCs

Sponsor: CT Department of Public Health

Authors: Laijun Lai

Funding: $886,531

2011-08-01 - 2014-10-01

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