Laijun Lai
Research Professor/Allied Health Sciences
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Scholarly Contributions
44 Scholarly Contributions
A CD300c-Fc Fusion Protein Inhibits T Cell Immunity
Laijun Lai,
, (2018). A CD300c-Fc Fusion Protein Inhibits T Cell Immunity, Front Immunol. 2018 Nov 15;9:2657, vol. 9, pp. 2657, The official Journal of the International Union of Immunological Societies (IUIS)
Research Type: Journal Article
A human recombinant IL-7/HGF alpha chain hybrid cytokine enhances T cell regeneration after bone marrow transplantation
Laijun Lai
, (2011). A human recombinant IL-7/HGF alpha chain hybrid cytokine enhances T cell regeneration after bone marrow transplantation, vol. 92, iss. 516-522, Transplantation
Research Type: Journal Article
A recombinant IL-7/IL-15 hybrid cytokine enhances antitumor immunity in mice
Laijun Lai,
, (2016). A recombinant IL-7/IL-15 hybrid cytokine enhances antitumor immunity in mice, Molecular Cancer Therapeutics, vol. 15, iss. 10, pp. 2413-2421, American Association of Cancer Research
Research Type: Journal Article
Administration of embryonic stem cell-derived thymic epithelial progenitors expressing MOG induces antigen-specific tolerance and ameliorates experimental autoimmune encephalomyelitis
Laijun Lai,
, (2015). Administration of embryonic stem cell-derived thymic epithelial progenitors expressing MOG induces antigen-specific tolerance and ameliorates experimental autoimmune encephalomyelitis, vol. 58, pp. 36-47, Journal of Autoimmunity
Research Type: Journal Article
BTNL2-Ig Protein Attenuates Type 1 Diabetes in Non-Obese Diabetic (NOD) Mice
Laijun Lai,
, (2019). BTNL2-Ig Protein Attenuates Type 1 Diabetes in Non-Obese Diabetic (NOD) Mice, Advanced Healthcare Materials, vol. 8, iss. 9, pp. 1800987, John Wiley & Sons, Inc
Research Type: Journal Article
CD300c ameliorates graft-versus-host disease
Laijun Lai
, (2019). CD300c ameliorates graft-versus-host disease, Autumn Immunology conference
Research Type: Poster/Presentation
CD300c is a negative regulator of T cell immunity
Laijun Lai
, (2019). CD300c is a negative regulator of T cell immunity, American Association of Immunologist Annual Meeting
Research Type: Poster/Presentation
Changes of immune parameters of T lymphocytes and macrophages in EAE mice after BM-MSCs transplantation.
Laijun Lai
, (2020). Changes of immune parameters of T lymphocytes and macrophages in EAE mice after BM-MSCs transplantation., Immunol Lett, vol. 225, pp. 66-73
Research Type: Journal Article
ERMAP is a B7 family-related molecule which negatively regulates T cell and macrophage responses.
Laijun Lai
, (2020). ERMAP is a B7 family-related molecule which negatively regulates T cell and macrophage responses., Cellular & Molecular Immunology, vol. 2020 Jul 3. doi: 10.1038/s41423-020-0494-8. Online ahead of print., Nature Publisher Group
Research Type: Journal Article
ESC-derived thymic epithelial cells expressing MOG prevents EAE by central and peripheral tolerance mechanisms
Laijun Lai,
, (2017). ESC-derived thymic epithelial cells expressing MOG prevents EAE by central and peripheral tolerance mechanisms, Cell Immunol, vol. 322, pp. 84-91
Research Type: Journal Article
Efficient in vitro generation of functional thymic epithelial progenitors from human embryonic stem cells
Laijun Lai,
, (2015). Efficient in vitro generation of functional thymic epithelial progenitors from human embryonic stem cells, vol. 5, pp. 9882-, Scientific Reports
Research Type: Journal Article
Expression of canonical WNT/beta-CATENIN signaling components in the developing human lung
Laijun Lai
, (2012). Expression of canonical WNT/beta-CATENIN signaling components in the developing human lung, vol. 12, iss. 1, pp. 21-25, BMC Dev Biol
Research Type: Journal Article
FOXN1 recombinant protein enhances T cell regeneration after bone marrow transplantation
Laijun Lai,
, (2016). FOXN1 recombinant protein enhances T cell regeneration after bone marrow transplantation, European Journal of Immunology, vol. 46, iss. 6, pp. 1518-1528, European Association of Immunologist
Research Type: Journal Article
Generation of thymic epithelial progenitors from embryonic stem cells
Laijun Lai
, (2014). Generation of thymic epithelial progenitors from embryonic stem cells, Master Class: stem cells and immune diseases
Research Type: Poster/Presentation
High expression of FAMLF is associated with clinical response in patients with de novo acute myeloid leukemia
Laijun Lai,
, (2016). High expression of FAMLF is associated with clinical response in patients with de novo acute myeloid leukemia, Leukemia & Lymphoma, vol. 57, iss. 11, pp. 2727-2730, Taylor & francis
Research Type: Journal Article
Hoxa3 is essential for the development of thymic epithelial progenitors from murine embryonic stem cells
Laijun Lai
, (2012). Hoxa3 is essential for the development of thymic epithelial progenitors from murine embryonic stem cells, International Society for Stem Cell Research 10th Annual Meeting, Japan
Research Type: Poster/Presentation
Hoxa3 is essential for the differentiation of thymic epithalial progenitors from embryonic stem cells
Laijun Lai
, (2012). Hoxa3 is essential for the differentiation of thymic epithalial progenitors from embryonic stem cells, ThymUS International Conference
Research Type: Poster/Presentation
Identification of TAPBPL as a novel negative regulator of T cell function
Laijun Lai
Identification of TAPBPL as a novel negative regulator of T cell function, EMBO Molecular Medicine
Research Type: Journal Article
In vivo administration of recombinant BTNL2-Fc fusion protein ameliorates graft-versus-host disease in mice
Laijun Lai,
, (2019). In vivo administration of recombinant BTNL2-Fc fusion protein ameliorates graft-versus-host disease in mice, Cellular Immunology, vol. 335, pp. 22-29, ELSEVIER
Research Type: Journal Article
Long Circulating Self-Assembled Nanoparticles from Cholesterol-Containing Brush-Like Block Copolymers for Improved Drug Delivery to Tumors
Laijun Lai,
Rajeswari Kasi,
Xiuling Lu
, (2014). Long Circulating Self-Assembled Nanoparticles from Cholesterol-Containing Brush-Like Block Copolymers for Improved Drug Delivery to Tumors, vol. 15, iss. 11, pp. 4363-4375
Research Type: Journal Article
Mouse embryonic stem cell-derived thymic epithelial cell progenitors enhance
Laijun Lai
, (2011). Mouse embryonic stem cell-derived thymic epithelial cell progenitors enhance, vol. 118, iss. 12, pp. 3410-3418, Blood
Research Type: Journal Article
New approaches to enhance T cell generation and functions
Laijun Lai
, (2016). New approaches to enhance T cell generation and functions, Beijing University School of Medicine Seminar, Asia
Research Type: Poster/Presentation
New approaches to prevent or treat autoimmunity diseases
Laijun Lai
, (2016). New approaches to prevent or treat autoimmunity diseases, Guiyang Medical College Seminar, Asia
Research Type: Poster/Presentation
Nucleic Acids Encoding a Chimeric Polypeptide Comprising IL-7 and HGF-beta Chain and Methods of Use
Laijun Lai
, (2011). Nucleic Acids Encoding a Chimeric Polypeptide Comprising IL-7 and HGF-beta Chain and Methods of Use
Research Type: Patent and Intellectual Property
Preventing Age-Associated Thymic Atrophy
Laijun Lai
, (2014). Preventing Age-Associated Thymic Atrophy, UCONN-Jackson Laboratory Aging Symposium.
Research Type: Poster/Presentation
Recombinant IL-7/HGFβ hybrid cytokine enhances T cell recovery following allogeneic hematopoietic stem cell transplantation. Plos ONE 8(12): e82998, 2013.
Laijun Lai,
, (2013). Recombinant IL-7/HGFβ hybrid cytokine enhances T cell recovery following allogeneic hematopoietic stem cell transplantation. Plos ONE 8(12): e82998, 2013., vol. 8, iss. 12, e82998, Plos ONE
Research Type: Journal Article
Recombinant IL-7/HGFβ hybrid cytokine separates acute graft-versus-host-disease from graft-versus-tumor activity by altering donor T cell trafficking
Laijun Lai,
, (2016). Recombinant IL-7/HGFβ hybrid cytokine separates acute graft-versus-host-disease from graft-versus-tumor activity by altering donor T cell trafficking, British Journal of Hematology, vol. 175, iss. 3, pp. 505-516, Wiley Online Library
Research Type: Journal Article
Recombinant IL-7/HGFβ hybrid cytokine separates acute graft-versus-host-disease from graft-versus-tumour activity by altering donor T cell trafficking.
Laijun Lai,
Xiuling Lu
, (2016). Recombinant IL-7/HGFβ hybrid cytokine separates acute graft-versus-host-disease from graft-versus-tumour activity by altering donor T cell trafficking., British journal of haematology, vol. 175, iss. 3, pp. 505-516
Research Type: Journal Article
Skint8, a Novel B7 Family-Related Molecule, Negatively Regulates T Cell Responses
Laijun Lai,
, (2019). Skint8, a Novel B7 Family-Related Molecule, Negatively Regulates T Cell Responses, J Immunol, vol. 203, iss. 2, pp. 400-407, The American Association of Immunologists, Inc.
Research Type: Journal Article
T cell regeneration after BMT is enhanced by embryonic stem cell-derived thymic epithelial cells
Laijun Lai
, (2012). T cell regeneration after BMT is enhanced by embryonic stem cell-derived thymic epithelial cells, Memorial Sloan-Kettering Cancer Center in New York
Research Type: Poster/Presentation
T cell regeneration after bone marrow transplantation
Laijun Lai
, (2013). T cell regeneration after bone marrow transplantation, Shanghai Medical University
Research Type: Poster/Presentation
T cell regeneration after hematopoietic stem cell transplantation
Laijun Lai
, (2013). T cell regeneration after hematopoietic stem cell transplantation, BIT 2nd Annual International Symposium of Hematology, China
Research Type: Poster/Presentation
Targeted deletion of C-met in thymic epithelial cells results in an autoimmune phenotype
Laijun Lai
, (2016). Targeted deletion of C-met in thymic epithelial cells results in an autoimmune phenotype, ThymUS2016
Research Type: Poster/Presentation
Targeted deletion of c-Met in thymic epithelial cells leads to an autoimmune phenotype.
Laijun Lai,
, (2018). Targeted deletion of c-Met in thymic epithelial cells leads to an autoimmune phenotype., Immunol Cell Biol., vol. 96, iss. 2, pp. 229-235
Research Type: Journal Article
Tbx1 Modulates Endodermal and Mesodermal Differentiation from Mouse Induced Pluripotent Stem cells
Laijun Lai,
, (2014). Tbx1 Modulates Endodermal and Mesodermal Differentiation from Mouse Induced Pluripotent Stem cells, vol. 23, iss. 13, pp. 1491-1500, Stem Cell and Developoment
Research Type: Journal Article
The recombinant IL-7/HGFb efficiently induces transplantable murine hematopoietic stem cells
Laijun Lai,
, (2012). The recombinant IL-7/HGFb efficiently induces transplantable murine hematopoietic stem cells, vol. 122, iss. 10, pp. 3553-3562, Journal of Clinical Investigation
Research Type: Journal Article
Transplantation of APP knock-out mouse embryonic stem cells derived thymic epithelial progenitors ameliorates Alzheimer's disease in mice.
Laijun Lai
, (2020). Transplantation of APP knock-out mouse embryonic stem cells derived thymic epithelial progenitors ameliorates Alzheimer's disease in mice., Frontiers in Immunology, vol. 11-Aug-20, iss. https://doi.org/10.3389/fimmu.2020.01781.
Research Type: Journal Article
Transplantation of MHC-mismatched Mouse Embryonic Stem Cell-Derived Thymic Epithelial Progenitors Prevents Autoimmune Diabetes
Laijun Lai,
, (2019). Transplantation of MHC-mismatched Mouse Embryonic Stem Cell-Derived Thymic Epithelial Progenitors Prevents Autoimmune Diabetes, Stem Cell Research and Therapy, vol. 10, iss. 1, pp. 10-Jan, Springer Nature
Research Type: Journal Article
Transplantation of donor-origin mouse embryonic stem cell-derived thymic epithelial progenitors prevents the development of chronic graft-versus-host disease in mice
Laijun Lai,
, (2017). Transplantation of donor-origin mouse embryonic stem cell-derived thymic epithelial progenitors prevents the development of chronic graft-versus-host disease in mice, Stem Cells Translational Medicine, vol. 6, iss. 1, pp. 121-130
Research Type: Journal Article
Using stem cell technology and gene engineering approaches to model and treat T cell immunodeficiency in the elderly
Laijun Lai
, (2019). Using stem cell technology and gene engineering approaches to model and treat T cell immunodeficiency in the elderly, Mayo Clinic
Research Type: Poster/Presentation
Using stem cell technology and gene engineering approaches to prevent and treat autoimmune diseases and cancer.
Laijun Lai
, (2017). Using stem cell technology and gene engineering approaches to prevent and treat autoimmune diseases and cancer., Department of Pathobiology & Veterinary Science, University of Connecticut
Research Type: Poster/Presentation
c-Met signaling is required for efficient postnal thymic regeneration and repair
Laijun Lai
, (2014). c-Met signaling is required for efficient postnal thymic regeneration and repair, ThymOz: International Workwork on lymphocytes
Research Type: Poster/Presentation
c-Met signaling is required for efficient postnatal thymic regeneration and repair in mice.
Laijun Lai,
, (2015). c-Met signaling is required for efficient postnatal thymic regeneration and repair in mice., vol. 144, iss. 2, pp. 245-253, Immunology
Research Type: Journal Article
c-Met signaling is required for thymopoiesis in aged mice
Laijun Lai
, (2014). c-Met signaling is required for thymopoiesis in aged mice, UCONN-Jackson Lab Aging Symposium
Research Type: Poster/Presentation