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Long non-coding RNAs in liver functions and diseases

Sponsor: UConn REP Program

Authors: xiaobo zhong, Jose E Manautou, Theodore Rasmussen, Li Wang

Funding: $50,000

2016-09-01 - 2017-08-31

Chromatin interaction, epigenomics, and transcriptional response to drug induction

Sponsor: University of Connecticut and Jackson Laboratory

Authors: xiaobo zhong, Xiuling Lu, Yijun Ruan, Guoliang Li

Funding: $250,000

2013-10-01 - 2018-09-30

Integrated liver-kidney human MPS to assess ADME and known toxicity profiles of FDA-approved ASO drugs

Sponsor: DHHS/NIH/National Institutes of Health/Javelin Biotech

Authors: Xiaobo Zhong

2025-12-01 - 2026-05-31

Integrated liver-kidney human MPS to assess ADME and known toxicity profiles of FDA-approved ASO drugs

Sponsor: DHHS/NIH/National Institutes of Health/Javelin Biotech

Authors: Xiaobo Zhong

2024-10-01 - 2025-03-31

Transcription Factor NFAT1 Deficiency and Osteoarthritis

Sponsor: DHHS/NIH/National Institute of Arthritis and Musculoskeletal and Skin Diseases/University of Kansas

Authors: Xiaobo Zhong

Funding: $14,972

2012-09-01 - 2016-05-31

Improvement of efficacy of ASO and siRNA drugs targeting liver cells

Sponsor: DHHS/NIH/National Institute of Diabetes and Digestive and Kidney Diseases

Authors: Xiaobo Zhong

2024-09-01 - 2029-08-31

Improvement of cellular uptake and trafficking of nucleotide drugs for better efficacy and less toxicity

Sponsor: DHHS/NIH/National Institutes of Health

Authors: Xiaobo Zhong

2022-09-01 - 2025-08-31

Posttranscriptional regulation of drug-metabolizing P450 enzymes by RNA methylation

Sponsor: DHHS/NIH/National Institutes of Health

Authors: Xiaobo Zhong

2019-09-01 - 2021-08-31

The role of IncRNAs in P450-mediated drug metabolism and drug-induced liver injury

Sponsor: DHHS/NIH/National Institutes of Health

Authors: Xiaobo Zhong

2026-02-01 - 2031-01-31

The roles of long non-coding RNAs in drug metabolism and toxicity

Sponsor: UConn Research Excellence Program

Authors: Xiaobo Zhong

Funding: $25,000

2020-09-01 - 2021-08-31

Impact of Drug Treatment at Neonatal Ages on Variability of Drug Metabolism and Drug Interactions in Adult Life

Sponsor: American Foundation for Pharmaceutical Education

Authors: Xiaobo Zhong

Funding: $10,000

2017-09-01 - 2018-08-31

The Role of H19, A Long Non-Coding RNA, in Postnatal Liver Maturation

Sponsor: DHHS/NIH/National Institutes of Health

Authors: Xiaobo Zhong

2016-07-01 - 2018-06-30

Regulation and Endogenous Functions of CYP3A7

Sponsor: DHHS/NIH/National Institutes of Health/University of Pittsburgh

Authors: Xiaobo Zhong

2025-12-01 - 2030-11-30

Short- or Long-Term Impacts of Drug Exposure at Early Life on Drug Metabolism, Therapeutic Efficacy, and Drug-Induced Toxicity

Sponsor: DHHS/NIH/National Institute of General Medical Sciences

Authors: Xiaobo Zhong

Funding: $1,986,412

2016-04-01 - 2020-01-31

The role of lncRNAs in P450-mediated drug metabolism and drug-induced liver injury

Sponsor: DHHS/NIH/National Institute of General Medical Sciences

Authors: Xiaobo Zhong

Funding: $2,012,500

2021-04-01 - 2026-01-31

Developmental Regulation of Drug Processing Genes

Sponsor: DHHS/NIH/National Institute of Environmental Health Sciences/University of Kansas, Medical Center Research Institute

Authors: Xiaobo Zhong

Funding: $351,855

2012-09-01 - 2014-06-30

The Role of Long Non-Coding RNAs in the Regulation of Drug Metabolism

Sponsor: DHHS/NIH/National Institutes of Health

Authors: Xiaobo Zhong

2018-07-01 - 2023-06-30

The impact on metabolism and toxicity of RNA-based drugs by RNA methylation

Sponsor: DHHS/NIH/National Institute of General Medical Sciences

Authors: Xiaobo Zhong

2020-01-01 - 2024-12-31

The role of long non-coding RNAs in the regulation of drug metabolism

Sponsor: DHHS/NIH/National Institutes of Health

Authors: Xiaobo Zhong

2017-09-01 - 2022-08-31

Posttranscriptional regulation of drug-metabolizing P450 enzymes by RNA methylation

Sponsor: DHHS/NIH/National Institute of Child Health and Human Development

Authors: Xiaobo Zhong

2019-07-01 - 2021-06-30

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