Dennis Wright
Professor/Pharmaceutical Science

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Scholarly Contributions

132 Scholarly Contributions

68
Journal Articles
46
Conference Proceedings
14
Poster/Presentations
3
Patent and Intellectual Propertys
1
Book
The tandem ring openingring closing metathesis route to oxaspirocycles An approach to phelligridin G
2013
Dennis Wright
Research Type: Journal Article

Structural analysis of the active sites of dihydrofolate reductase from two species of Candida uncovers ligandinduced conformational changes shared among species
2013
Janet Paulsen, Amy Anderson, Kishore Viswanathan, Dennis Wright
Research Type: Journal Article

Tropolones as lead-like natural products: the development of potent and selective histone deacetylase inhibitors.
2013
M Ammar, Amy Anderson, Dennis Wright, W Zhou, E Z Oblak, S N Ononye, M D VanHeyst
Research Type: Journal Article

Structural analysis of the active sites of dihydrofolate reductase from two species of Candida uncovers ligand-induced conformational changes shared among species.
2013
Amy Anderson, J L Paulsen, Dennis Wright, K Viswanathan
Research Type: Journal Article

Inhibitors of Dihydrofolate Reductase with Antibacterial, Antiprotozoal, Antifungal and Anticancer Properties
2013
Dennis Wright
Research Type: Patent and Intellectual Property

Crystal structures of Klebsiella pneumoniae dihydrofolate reductase bound to propargyl-linked antifolates reveal features for potency and selectivity.
2014
Michael Lombardo, Amy Anderson, N D Priestley, J Alverson, Dennis Wright, K M Lamb
Research Type: Journal Article

Antifolate agents: a patent review (2010 - 2013).
2014
Dennis Wright, Amy Anderson
Research Type: Journal Article

Cyclopropene cycloadditions with annulated furans: total synthesis of (+)- and (-)-frondosin B and (+)-frondosin a
2014
E Zachary Oblak, Michael D VanHeyst, Jin Li, Dennis Wright, Andrew Wiemer
Research Type: Journal Article

Deoxygenation/methylation of heteroaryl propargyl alcohols: Methods to generate unsubstituted, mono-, and di-methylated alkynes
2014
Dennis Wright, Narendran G-Dyanana, Eric Scocchera
Research Type: Poster/Presentation

Tandem metathesis reaction to construct the spirocyclic core of cyclopamine
2014
Narendarn G-Dyanaa, Dennis Wright, Edward Oblak
Research Type: Poster/Presentation

Propargyl linked antifolates are dual inhibitors of Candida albicans and Candida glabrata
2014
Narendarn G-Dyanan, Dennis Wright
Research Type: Poster/Presentation

Cyclopropene cycloadditions with annulated furans: Total synthesis of (+) frondosin A and (+) and (-) frondosin B
2014
Dennis Wright, Micahael VanHeyst
Research Type: Poster/Presentation

Development of intestinal organoids as tissue surrogates: cell composition and the epigenetic control of differentiation.
2015
Wanli Xu, Jason D Gibson, Dennis Wright, L Cao, F Kolling, 4th, A Kuratnik, M D Van Heyst, E R Falcone, M Ammar, Charles A Giardina, C E Nelson
Research Type: Journal Article

Measuring propargyl-linked drug populations inside bacterial cells, and their interaction with a dihydrofolate reductase target, by Raman microscopy.
2015
H Heidari-Torkabadi, P R Carey, Michael Lombardo, T Che, Dennis Wright, Amy Anderson
Research Type: Journal Article

MRSA Isolates from United States Hospitals Carry dfrG and dfrK Resistance Genes and Succumb to Propargyl-Linked Antifolates.
2016
Amy Anderson, Jeffrey R Aeschlimann, Dennis Wright, S Keshipeddy, E W Scocchera, B Hajian, J Ferreira, N G-Dayanadan, J Krucinska, S M Reeve, Michael D Nailor
Research Type: Journal Article

Novel α-substituted tropolones promote potent and selective caspase-dependent leukemia cell apoptosis.
2016
E R Falcone, S A Holstein, Andrew Wiemer, J Li, Amy Anderson, Dennis Wright
Research Type: Journal Article

MRSA isolates from the United States hospitals carry dfrG and drfK resistance genes and succumb to propargyl-linked antifolates
2016
S M Reeve, Jeffrey R Aeschlimann, Michael D Nailor, Amy Anderson, J Ferreira, J Krucinska, N G Dayanadan, B Hajjan, E W Scocchera, S Keshipeddy, Dennis Wright
Research Type: Journal Article

Propargyl-Linked Antifolates Are Potent Inhibitors of Drug-Sensitive and Drug-Resistant Mycobacterium tuberculosis.
2016
Amy Anderson, S Reeve, Dennis Wright, J Krucinska, B Hajian, C Shoen, M Cynamon, N G-Dayanandan, S Keshipeddy, E Scocchera
Research Type: Journal Article

The exonuclease activity of HSV-1 UL12 is required for the production of viral DNA that can be packaged to produce infectious virus
2017
L. M. Grady, S. K. Weller, R. Szczepaniak, Dennis Wright, R. P. Murelli, T. Masaoka
Research Type: Journal Article

Pharmaceutical analysis of a novel propargyl-linked antifolate antibiotic in the mouse
2017
N. D. Priestley, S. Keshipeddy, J. B. Alverson, Dennis Wright, Amy Anderson, P. A. Barney, J. Hoody, L. Walker
Research Type: Journal Article