Dennis Wright
Professor/Pharmaceutical Science

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Novel guanidine compounds inhibit platelet-derived growth factor receptor alpha transcription and oligodendrocyte precursor cell proliferation.
2021
A Sherafat, W M Wood, S Sakya, Jingfeng Song, J Medved, Akiko Nishiyama, Dennis Wright, M D van Heyst
Research Type: Journal Article

Two-Metal Ion-Dependent Enzymes as Potential Antiviral Targets in Human Herpesviruses.
2022
S Weerasooriya, Lee Wright, A Hazeen, K A DiScipio, S K Weller, Dennis Wright, R Szczepaniak
Research Type: Journal Article

Chiral evasion and stereospecific antifolate resistance in Staphylococcus aureus.
2022
V G Fowler, S M Reeve, M S Frenkel, A A Ojewole, Dennis Wright, S Keshipeddy, B R Donald, G T Holt, P Gainza, Shuwen Wang
Research Type: Journal Article

Structure-guided functional studies of plasmid-encoded dihydrofolate reductases reveal a common mechanism of trimethoprim resistance in Gram-negative pathogens.
2022
Dennis Wright, A Estrada, J Krucinska, H Erlandsen, K Viswanathan, D Si, Michael Lombardo
Research Type: Journal Article

Heterocyclic Enzyme Inhibitors Targeting Drug Resistant Pathogens
2022
Research Type: Poster/Presentation

HMGB2 is a potential diagnostic marker and therapeutic target for liver fibrosis and cirrhosis.
2023
Yen Chih Huang, N Huda, Antonio P Costa, Dennis Wright, S K Keshipeddy, J Ma, Diane J Burgess, S Rudraiah, Y Zhang, L Wang, Zhihong Yang, S Liangpunsakul
Research Type: Journal Article

Photocurable hard and porous biomaterials from ROMP precursors crosslinked with diyl radicals
Research Type: Conference Proceedings

Annulated heterocycles through a radicalcation cyclization synthetic and mechanistic studies
Research Type: Conference Proceedings

Altered specificity of HintW123Q supports a role for Hint inhibition by ASW in avian sex determination
Research Type: Conference Proceedings

Crystal Structures of Wildtype and Mutant Methicillinresistant Staphylococcus aureus Dihydrofolate Reductase Reveal an Alternate Conformation of NADPH That May Be Linked to Trimethoprim Resistance
Amy Anderson, Michael Lombardo, Dennis Wright
Research Type: Conference Proceedings

Electrochemical annulation of fivemembered rings through dearomatization of furans and thiophenes
Research Type: Conference Proceedings

Selenium concentration of fescue and bahiagrasses after applying a selenium fertilizer
Research Type: Conference Proceedings

Chapter 1 Furans as versatile synthons for targetoriented and diversityoriented synthesis
Research Type: Conference Proceedings

Synthesis of functionalized pyrans by domino metathesis reaction of oxabicyclo derivatives Dramatic effect of remote substituents on reactivity and selectivity
Research Type: Conference Proceedings

Facile generation of aziridines from the reaction of diazoamides with tethered oximinoethers
Research Type: Conference Proceedings

Towards the understanding of resistance mechanisms in clinically isolated trimethoprimresistant methicillinresistant Staphylococcus aureus dihydrofolate reductase
Amy Anderson, Michael Lombardo, Dennis Wright
Research Type: Conference Proceedings

Halogenated oxabicyclo321octadiene building blocks Elaboration of the dibromoenone
Research Type: Conference Proceedings

Studies on the DielsAlder reaction of annulated furans Application to the synthesis of substituted phenanthrenes
Research Type: Conference Proceedings

Oxabicyclo321octane derivatives as highly reactive dienophiles Synthesis of bicyclo5n0 systems
Research Type: Conference Proceedings

Unusual influence of substituents on ringopening metathesis reactions
Research Type: Conference Proceedings