Dennis Wright
Professor/Pharmaceutical Science

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Scholarly Contributions

132 Scholarly Contributions

68
Journal Articles
46
Conference Proceedings
14
Poster/Presentations
3
Patent and Intellectual Propertys
1
Book
Characterization of trimethoprim resistant E. coli dihydrofolate reductase mutants by mass spectrometry and inhibition by propargyl-linked antifolates
2017
Amy Anderson, M. Cammarata, J. S. Brodbelt, Michael Lombardo, A. Ellington, Dennis Wright, R. Thyer
Research Type: Journal Article

MRSA Isolates from United States Hospitals Carry dfrG and dfrK Resistance Genes and Succumb to Propargyl-Linked Antifolates.
2016
Amy Anderson, Jeffrey R Aeschlimann, Dennis Wright, S Keshipeddy, E W Scocchera, B Hajian, J Ferreira, N G-Dayanadan, J Krucinska, S M Reeve, Michael D Nailor
Research Type: Journal Article

Novel α-substituted tropolones promote potent and selective caspase-dependent leukemia cell apoptosis.
2016
E R Falcone, S A Holstein, Andrew Wiemer, J Li, Amy Anderson, Dennis Wright
Research Type: Journal Article

MRSA isolates from the United States hospitals carry dfrG and drfK resistance genes and succumb to propargyl-linked antifolates
2016
S M Reeve, Jeffrey R Aeschlimann, Michael D Nailor, Amy Anderson, J Ferreira, J Krucinska, N G Dayanadan, B Hajjan, E W Scocchera, S Keshipeddy, Dennis Wright
Research Type: Journal Article

Propargyl-Linked Antifolates Are Potent Inhibitors of Drug-Sensitive and Drug-Resistant Mycobacterium tuberculosis.
2016
Amy Anderson, S Reeve, Dennis Wright, J Krucinska, B Hajian, C Shoen, M Cynamon, N G-Dayanandan, S Keshipeddy, E Scocchera
Research Type: Journal Article

Development of intestinal organoids as tissue surrogates: cell composition and the epigenetic control of differentiation.
2015
Wanli Xu, Jason D Gibson, Dennis Wright, L Cao, F Kolling, 4th, A Kuratnik, M D Van Heyst, E R Falcone, M Ammar, Charles A Giardina, C E Nelson
Research Type: Journal Article

Measuring propargyl-linked drug populations inside bacterial cells, and their interaction with a dihydrofolate reductase target, by Raman microscopy.
2015
H Heidari-Torkabadi, P R Carey, Michael Lombardo, T Che, Dennis Wright, Amy Anderson
Research Type: Journal Article

Crystal structures of Klebsiella pneumoniae dihydrofolate reductase bound to propargyl-linked antifolates reveal features for potency and selectivity.
2014
Michael Lombardo, Amy Anderson, N D Priestley, J Alverson, Dennis Wright, K M Lamb
Research Type: Journal Article

Antifolate agents: a patent review (2010 - 2013).
2014
Dennis Wright, Amy Anderson
Research Type: Journal Article

Cyclopropene cycloadditions with annulated furans: total synthesis of (+)- and (-)-frondosin B and (+)-frondosin a
2014
E Zachary Oblak, Michael D VanHeyst, Jin Li, Dennis Wright, Andrew Wiemer
Research Type: Journal Article

The tandem ring openingring closing metathesis route to oxaspirocycles An approach to phelligridin G
2013
Dennis Wright
Research Type: Journal Article

Structural analysis of the active sites of dihydrofolate reductase from two species of Candida uncovers ligandinduced conformational changes shared among species
2013
Janet Paulsen, Amy Anderson, Kishore Viswanathan, Dennis Wright
Research Type: Journal Article

Tropolones as lead-like natural products: the development of potent and selective histone deacetylase inhibitors.
2013
M Ammar, Amy Anderson, Dennis Wright, W Zhou, E Z Oblak, S N Ononye, M D VanHeyst
Research Type: Journal Article

Structural analysis of the active sites of dihydrofolate reductase from two species of Candida uncovers ligand-induced conformational changes shared among species.
2013
Amy Anderson, J L Paulsen, Dennis Wright, K Viswanathan
Research Type: Journal Article

Acetylenic linkers in lead compounds A study of the stability of the propargyllinked antifolates
2012
Dennis Hill, Wangda Zhou, Amy Anderson, Kishore Viswanathan, Dennis Wright
Research Type: Journal Article

Acetylenic linkers in lead compounds: a study of the stability of the propargyl-linked antifolates.
2012
K Viswanathan, W Zhou, Dennis Hill, Amy Anderson, Dennis Wright
Research Type: Journal Article

Synthesis of a functionalized oxabicyclo221heptenebased chemical library
2012
Dennis Wright
Research Type: Journal Article

Viridin analogs derived from steroidal building blocks
2012
Dennis Wright, Amy Anderson
Research Type: Journal Article

Nonpeptidic lysosomal modulators derived from ZPheAladiazomethylketone for treating protein accumulation diseases
2012
Dennis Wright
Research Type: Journal Article

Toward new Therapeutics for Skin and Soft Tissue Infections: Propargyl-linked Antifolates Are Potent Inhibitors of MRSA and Streptococcus pyogenes
2012
Brooke Martin, Dennis Wright, Eric Scocchera, Amy Anderson, Jeremy Alverson, Nigel Priestley, P Swain, Kathleen Frey, Kishore Viswanathan
Research Type: Journal Article